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Sex-related Differences in Gene Expression in Salivary Glands of BALB/c Mice

¹ Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA, USA;
² Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA;
³ Department of Ophthalmology, Harvard Medical School, Boston, MA, USA;
⁴ Center for Neurologic Diseases, Brigham and Women’s Hospital and Harvard Medical School, Cambridge, MA, USA; and
⁵ Department of Physics, Wesleyan University, Middletown, CT, USA;

^* corresponding author, ntreister{at}partners.org

Sex-related differences exist in the structure and function of the major glands in a variety of species. Moreover, many of these variations appear to be unique to each tissue. We hypothesized that this sexual dimorphism is due, at least in part, to gland-specific differences in gene expression between males and females. Glands were collected from male and female BALB/c mice (n = 5/sex/experiment), and total RNA was isolated. Samples were analyzed for differentially expressed mRNAs with CodeLink microarrays, and data were evaluated by GeneSifter. Our results demonstrate that significant (P < 0.05) sex-related differences exist in the expression of numerous genes in the major salivary glands, and many of these differences were tissue-specific. These findings support our hypothesis that sex-related differences in the salivary glands are due, at least in part, to tissue-specific variations in gene expression.

KEY WORDS: salivary glands • microarrays • gene expression • sex differences

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