JDR JDR Most Read Articles
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via ISI Web of Science (2)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ogino, M.
Right arrow Articles by Kataoka, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ogino, M.
Right arrow Articles by Kataoka, M.
J Dent Res 84(12):1183-1186, 2005
© 2005 International and American Associations for Dental Research

RESEARCH REPORT
Biological

{alpha}2 Integrin +807 Polymorphism in Drug-induced Gingival Overgrowth

M. Ogino1,2, J. Kido2, M. Bando2, N. Hayashi2, C. Wada2, T. Nagata2, F. Nishimura3, Y. Soga3, S. Takashiba3, T. Kubota4, M. Itagaki4, Y. Shimada4, H. Tai4, H. Yoshie4, N. Yamazaki5, Y. Shinohara1, and M. Kataoka1,*

1 Divison of Gene Expression, Institute for Genome Research, The University of Tokushima, Kuramoto 3-18-15, Tokushima 770-8503, Japan;
2 Department of Periodontology and Endodontology, Institute of Health Bioscience, Graduate School, The University of Tokushima;
3 Department of Pathophysiology/Periodontal Science, Okayama University Graduate School of Medical and Dentistry;
4 Divison of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan; and
5 Faculty of Pharmaceutical Science, University of Tokushima, Japan;

* corresponding author, kataoka{at}genome.tokushima-u.ac.jp

{alpha}2 integrin on fibroblasts is reported to play an important role in the induction of drug-induced gingival overgrowth, which is characterized by excessive accumulation of type I collagen in gingival connective tissue. Silent polymorphism 807 T/C within the {alpha}2 integrin gene is associated with high/low {alpha}2 integrin expression. The aim of this study was to test the hypothesis that expression of {alpha}2 integrin 807 T/C polymorphism correlates with drug-induced gingival overgrowth. A case-control study comparing 136 subjects taking calcium channel blockers (72 with vs. 64 without drug-induced gingival overgrowth) demonstrated that the frequency of the +807 C allele was significantly higher in the case group than in the controls (odds ratio, 3.61; 95% confidence interval, 2.14 – 6.10; P < 0.05). The present findings suggest that the {alpha}2 +807 C allele is one of the genetic risk factors for drug-induced gingival overgrowth.

KEY WORDS: drug-induced gingival overgrowth • {alpha}2 integrin • SNP • collagen phagocytosis






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
IADR Journals Advances in Dental Research ®
Journal of Dental Research ® Critical Reviews (1990-2004)
Copyright © 2005 Institutional Access Guidelines