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Expression of SIBLINGs and Their Partner MMPs in Salivary Glands

Craniofacial and Skeletal Diseases Branch, Building 30, Room 228, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, 9000 Rockville Pike, Bethesda, MD 20892-4320, USA;

^* corresponding author, lfisher{at}dir.nidcr.nih.gov

Three members of the SIBLING family of integrin-binding phosphoglycoproteins (bone sialoprotein, BSP; osteopontin, OPN; and dentin matrix protein-1, DMP1) were recently shown to bind with high affinity (nM) and to activate 3 different matrix metalloproteinases (MMP-2, MMP-3, and MMP-9, respectively) in vitro. The current study was designed to document the possible biological relevance of the SIBLING-MMP activation pathway in vivo by showing that these 3 SIBLINGs and their known MMP partners are co-expressed in normal adult tissue. BSP, OPN, and DMP1 were invariably co-expressed with their partner MMPs in salivary glands of humans and mice. The 2 SIBLING proteins without known MMP partners, dentin sialophosphoprotein (DSPP) and matrix extracellular phosphoglycoprotein (MEPE), were also expressed in salivary glands. Expression of all SIBLINGs in this normal, non-mineralizing epithelial tissue suggests that they serve at least one function in vivo other than directly promoting matrix mineralization—a function we hypothesize involves local activation of MMPs.

KEY WORDS: SIBLING • MMP • bone sialoprotein • osteopontin • dentin matrix protein-1

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