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Clonal Persistence of Oral Fusobacterium nucleatum in Infancy

¹ Anaerobe Reference Laboratory, National Public Health Institute (KTL), Helsinki, Finland;
² Faculty of Odontology, University of Iceland, Vatnsmyrarvegur 16 IS 101 Reykjavik, Iceland; and
³ Faculty of Dentistry, Kuwait University, Kuwait;

^* corresponding author, gah{at}hi.is

Once established, early-colonizing bacterial species tend to persist in the mouth. To obtain detailed information on the population dynamics of early-colonizing oral anaerobes, we examined the clonal diversity and persistence of clones among oral Fusobacterium nucleatum populations during the first 2 yrs of life. Consecutive salivary samples from 12 infants, collected at 2, 6, 12, 18, and 24 mos of age, yielded a total of 546 F. nucleatum isolates for clonal typing with arbitrarily primed PCR (AP-PCR). Up to 7 AP-PCR types were simultaneously detected in each sample. In 11 out of the 12 infants examined, AP-PCR types persisted for up to 1 yr. Strain turnover rate was high during the first year of life, but then the occurrence of persistent clones increased. This study indicates a wide genetic diversity within the species and provides evidence for the increasing persistence of F. nucleatum clones in the oral cavity with age.

KEY WORDS: Fusobacterium nucleatum • clonal diversity • clonal persistence • infants • AP-PCR

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