JDR JDR Most Read Articles
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Appendix
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Di Nardo Di Maio, F.
Right arrow Articles by Felaco, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Di Nardo Di Maio, F.
Right arrow Articles by Felaco, M.
J Dent Res 83(4): 312-316, 2004
© 2004 International and American Associations for Dental Research

RESEARCH REPORT
Clinical

Nitric Oxide Synthase in Healthy and Inflamed Human Dental Pulp

F. Di Nardo Di Maio, Z. Lohinai1, C. D’Arcangelo, P. Esposito De Fazio, L. Speranza2, M.A. De Lutiis2, A. Patruno2, A. Grilli2, and M. Felaco2,*

1 Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, 78/A Üllôi út, Budapest, Hungary, 1082; and
2 School of Dentistry, University of Chieti, 1 Via dei Vestini, Chieti, Italy, 66100;

* corresponding author, mfelaco{at}unich.it

Nitric oxide synthase (NOS) plays a significant role in the pathogenesis of pulpitis. In this study, we hypothesized the existence of endothelial (eNOS) and inducible (iNOS) enzyme isoforms in human dental pulp. Extracted third molar pulps were divided into groups based on clinical diagnosis: healthy, hyperemic, and irreversible pulpitis. We have localized the eNOS and iNOS by immunohistochemistry and have tested their mRNA expression by RT-PCR and protein levels by Western blots. eNOS is present in the endothelial cells and odontoblasts of the healthy pulp, but an elevation of eNOS mRNA and protein levels with a concomitant dilation of vessels was characteristic under pathological conditions. Healthy pulp tissue failed to exhibit any iNOS; however, acute inflammation enhanced the mRNA and protein levels of iNOS, mainly in the leukocytes. There are differences in localization and expression between eNOS and iNOS in healthy and inflamed dental pulp.

KEY WORDS: nitric oxide synthase • human dental pulp • inflammation • endothelial cells • odontoblast




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
O. Khorram, N. Khorram, M. Momeni, G. Han, J. Halem, M. Desai, and M. G. Ross
Maternal undernutrition inhibits angiogenesis in the offspring: a potential mechanism of programmed hypertension
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2007; 293(2): R745 - R753.
[Abstract] [Full Text] [PDF]

Home page
 J. Dent. Res.Home page
R. Yasuhara, T. Suzawa, Y. Miyamoto, X. Wang, M. Takami, A. Yamada, and R. Kamijo
Nitric Oxide in Pulp Cell Growth, Differentiation, and Mineralization
J. Dent. Res., February 1, 2007; 86(2): 163 - 168.
[Abstract] [Full Text] [PDF]

Home page
 J. Dent. Res.Home page
N. Kawashima, H. Nakano-Kawanishi, N. Suzuki, M. Takagi, and H. Suda
Effect of NOS Inhibitor on Cytokine and COX2 Expression in Rat Pulpitis
J. Dent. Res., August 1, 2005; 84(8): 762 - 767.
[Abstract] [Full Text] [PDF]

Home page
 J. Dent. Res.Home page
Y. Korkmaz, M.A. Baumann, D. Steinritz, H. Schroder, S. Behrends, K. Addicks, K. Schneider, W.H.-M. Raab, and W. Bloch
NO-cGMP Signaling Molecules in Cells of the Rat Molar Dentin-Pulp Complex
J. Dent. Res., July 1, 2005; 84(7): 618 - 623.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
IADR Journals Advances in Dental Research ®
Journal of Dental Research ® Critical Reviews (1990-2004)
Copyright © 2004 Institutional Access Guidelines