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J Dent Res 83(2): 161-165, 2004
© 2004 International and American Associations for Dental Research

RESEARCH REPORT
Clinical

Association of ALDH2 Genotypes and Alcohol Consumption with Periodontitis

N. Nishida1, M. Tanaka1, N. Hayashi1, H. Nagata1, T. Takeshita2,3, K. Nakayama2, K. Morimoto2, and S. Shizukuishi1,*

1 Department of Preventive Dentistry, Osaka University Graduate School of Dentistry, 1-8, Yamadaoka, Suita, Osaka 565-0871, Japan; and
2 Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine;

* corresponding author, shizuku{at}dent.osaka-u.ac.jp

There is little information regarding the association between alcohol consumption and periodontitis risk. We assessed whether alcohol consumption and ALDH2 genotypes were associated with periodontitis. Subjects’ lifestyle was examined by a self-administered questionnaire, and the percentage of pocket depths >= 3.5 mm was used as a periodontal parameter. ALDH2 genotypes were determined with the use of a PCR/RFLP method. Multiple logistic analyses showed that alcohol consumption was significantly associated with periodontitis, and its odds ratio was 1.98. There was no significant relationship between periodontal status and ALDH2 genotypes. However, ALDH2*1/*2 subjects who consumed >= 33 g/day of alcohol had a significantly greater percentage of pocket depths >= 3.5 mm than those whose daily consumption was lower, while there was no significant difference in periodontal status associated with alcohol consumption in ALDH2*1/*1 subjects. Our results suggest that alcohol consumption may be a risk indicator for periodontitis in ALDH2*1/*2 subjects who consume larger amounts of alcohol.

KEY WORDS: alcohol consumption • periodontitis • ALDH2 genotype • epidemiology






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