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Chondroitin Sulfate in Palatal Wound Healing

¹ Faculty of Dentistry, National University of Singapore, Singapore;
² Department of Anatomy, Faculty of Medicine, National University of Singapore, 4 Medical Drive, Block MD 10, Singapore 117597, Singapore; and
³ Division of Bioengineering, Faculty of Engineering, National University of Singapore, Singapore;

^* corresponding author, georgeyip{at}nus.edu.sg.

Chondroitin sulfate is up-regulated in granulation tissue during wound healing. To investigate the role of chondroitin sulfate in the wound-healing process after surgical repair of cleft palate, we isolated and cultured rabbit palatal fibroblasts. Treatment with chondroitin-6-sulfate resulted in a dose-dependent increase in cell adhesion and cell proliferation, whereas the reverse effects were seen after chondroitinase degradation of chondroitin sulfate. The biological actions of chondroitin sulfate appeared to be dependent on the presence and position of sulfate groups. Inhibition of glycosaminoglycan sulfation by chlorate treatment led to reduced cell adhesion and cell proliferation and a slower rate of wound closure in vitro. Furthermore, exposure to chondroitin-4-sulfate resulted in a dose-dependent reduction in cell adhesion. Together, these results show that chondroitin sulfate is involved in palatal wound healing.

KEY WORDS: chondroitin sulfate • chlorate • wound healing • cell adhesion • cell proliferation

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