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Mouse Cellular Cementum is Highly Dependent on Growth Hormone Status

¹ School of Dentistry,
² School of Biomedical Sciences, and
³ Institute for Molecular Bioscience, University of Queensland, St. Lucia, Brisbane, Queensland 4072, Australia;
⁴ Edison Biotechnology Institute; and
⁵ Department of Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Athens, OH, USA;

^* corresponding author, j.smid{at}mailbox.uq.edu.au

Cementum is known to be growth-hormone (GH)-responsive, but to what extent is unclear. This study examines the effects of extremes of GH status on cementogenesis in three lines of genetically modified mice; GH excess (giant), GH antagonist excess (dwarf), and GH receptor-deleted (GHR-KO) (dwarf). Age-matched mandibular molar tissues were processed for light microscope histology. Digital images of sections of first molar teeth were captured for morphometric analysis of lingual root cementum. Cross-sectional area of the cellular cementum was a sensitive guide to GH status, being reduced nearly 10-fold in GHR-KO mice, three-fold in GH antagonist mice, and increased almost two-fold in giant mice (p < 0.001). Cellular cementum length was similarly influenced by GH status, but to a lesser extent. Acellular cementum was generally unaffected. This study reveals cellular cementum to be a highly responsive GH target tissue, which may have therapeutic applications in assisting regeneration of the periodontium.

KEY WORDS: cementum • growth hormone • GH transgenic mice • GH receptor knockout mice

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