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J Dent Res 82(9): 692-696, 2003
© 2003 International and American Associations for Dental Research

RESEARCH REPORT
Biomaterials & Bioengineering

Behavior of SaOS-2 Cells Cultured on Different Titanium Surfaces

L. Postiglione1,*, G. Di Domenico1, L. Ramaglia2, S. Montagnani3, S. Salzano4, F. Di Meglio3, L. Sbordone5, M. Vitale1, and G. Rossi1

1 Dept. of Cellular and Molecular Biology and Pathology, "L. Califano",
2 Dept. of Dental and Maxillofacial Sciences,
3 Dept. of Biomorphological Sciences, and
4 CNR/IEOS "G. Salvatore", University of Naples "Federico II", via S. Pansini 5, 80131 Naples, Italy; and
5 Dept. of Periodontics, University of Pisa, Italy;

* corresponding author, lorposti{at}unina.it

Surface properties may affect the clinical outcome of titanium dental implants. The aim of the present study was to investigate the effects of 3 different titanium surfaces—smooth (S), sandblasted (SB), and titanium plasma-sprayed (TPS)—on proliferation, differentiation, and apoptosis of human osteoblast-like cells, SaOS-2. Cell proliferation was significantly (p < 0.05) higher on the S surface, and synthesis of extracellular matrix proteins was more abundant on TPS and SB than on S surfaces. Analysis of integrin receptors showed a higher expression of {alpha}2, {alpha}5, {alpha}Vß3, and ß1 on TPS as compared with SB and S surfaces. An increase in alkaline phosphatase activity was detected only on SB and TPS surfaces. Analysis of cell apoptosis did not demonstrate any significant difference among the 3 different surfaces. The results indicate that titanium surface topography affects proliferation and differentiation of osteoblast-like SaOS-2 cells, suggesting that surface properties might be important for bone response around dental implants in vivo.

KEY WORDS: titanium surfaces • osteoblasts • cell growth • cell differentiation • cell apoptosis






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