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TGF-ß1 Induces Accumulation of Dendritic Cells in the Odontoblast Layer

¹ Laboratory of Development of Dental Tissues, EA MENRT 1892, IFR 62, Faculty of Odontology, Lyon 1 University, G. Paradin Str., 69372 Lyon Cedex 08, France; and
² Schering-Plough Corp., Laboratory for Immunological Research, 69571 Dardilly, France;

^* corresponding author, farges{at}laennec.univ-lyon1.fr

TGF-ß1 released from dentin degraded by bacterial or iatrogenic agents is suspected to influence dental pulp response, including the modulation of cell migration. To determine the consequences of TGF-ß1 action on pulp immune cells, we analyzed, by immunohistochemistry, the effect of transdentinally diffusing TGF-ß1 on their localization in a human tooth slice culture model. TGF-ß1 induced an accumulation of HLA-DR-positive cells in both odontoblast and subodontoblast layers of the stimulated zone. Together with HLA-DR, these cells co-expressed Factor XIIIa and CD68, two features of immature antigen-presenting dendritic cells (DC), as well as the TGF-ß1 specific receptor TßRII. In contrast, no effect could be detected on the localization of either mature DC-LAMP-positive DC or of T- and B-lymphocytes. Analysis of these data suggests that TGF-ß1 released from dentin degraded by bacterial or iatrogenic agents could be involved in the immune response of the dental pulp resulting from tooth injury.

KEY WORDS: tooth pulp • immune response • HLA-DR • TGF receptor • chemokine

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