HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Services Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (13) Citing Articles via Google Scholar Google Scholar Articles by Yamazaki, K. Articles by Seymour, G.J. Search for Related Content PubMed PubMed Citation Articles by Yamazaki, K. Articles by Seymour, G.J.

Single-nucleotide Polymorphism in the CD14 Promoter and Periodontal Disease Expression in a Japanese Population

¹ Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, 5274, Gakkocho-Dori 2-ban-cho, Niigata 951-8514, Japan;
³ Oral Biology and Pathology, Department of Dentistry, The University of Queensland, Brisbane, Australia;

^* corresponding author, kaz{at}dent.niigata-u.ac.jp

It has been reported that there is a relationship between a single-nucleotide polymorphism (SNP) in the promoter region of the CD14 gene at position -159 (CT) and infectious diseases. The aim of the present study was to test the hypthesis that expression of this SNP correlates with periodontal disease in a Japanese population. The CD14 genotype was determined in 163 subjects with periodontitis and in 104 age- and gender-matched control subjects without periodontitis. The genotype distribution and allele frequency within the periodontitis patients were not significantly different from those of control subjects. There was, however, a significant difference in the genotype distribution between young patients (< 35 yrs) and older patients ( 35 yrs). These findings suggest that CD14 -159C/T polymorphism is not related to the development of periodontitis in a Japanese population, but that, within the periodontitis subjects, expression of the SNP may be related to early disease activity.

KEY WORDS: CD14 • polymorphism • chronic periodontitis • Japanese

This article has been cited by other articles:

				M.L. Laine, S.A. Morre, L.S. Murillo, A.-J. van Winkelhoff, and A.S. Pena CD14 and TLR4 Gene Polymorphisms in Adult Periodontitis J. Dent. Res., November 1, 2005; 84(11): 1042 - 1046. [Abstract] [Full Text] [PDF]