HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Services Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (6) Citing Articles via Google Scholar Google Scholar Articles by Korfage, J.A.M. Articles by Van Eijden, T.M.G.J. Search for Related Content PubMed PubMed Citation Articles by Korfage, J.A.M. Articles by Van Eijden, T.M.G.J.

Myosin Heavy-chain Isoform Composition of Human Single Jaw-muscle Fibers

Department of Functional Anatomy, Academic Center for Dentistry Amsterdam (ACTA), Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands;

*corresponding author, j.a.korfage{at}amc.uva.nl

Diversity in muscle contractile properties is based on the variability of contractile properties of single muscle fibers which in turn is related to the presence of different myosin heavy-chain (MyHC) isoforms. Human jaw muscles are featured by many hybrid fibers expressing more than one MyHC isoform. The purpose of this study was to determine the proportion of each isoform within these fibers for evaluation of the fiber’s capacity of producing a large diversity in contractile properties. Electrophoretic separation of MyHC isoforms was performed on 218 single fibers of the temporalis and digastric muscles. Of these fibers, 100 were classified as hybrid fibers. Most hybrid fibers co-expressed MyHC-IIA and -IIX (n = 62); a smaller number co-expressed MyHC-I and -IIA (n = 14), MyHC-I and -IIX (n = 12), and MyHC-I, -IIA, and -IIX (n = 12). The proportions of the individual MyHC isoforms in the hybrid fibers varied highly, suggesting a large range of contractile properties among these fibers.

KEY WORDS: myosin • single muscle fiber • gel electrophoresis

This article has been cited by other articles:

				J.A.M Korfage, J.H. Koolstra, G.E.J. Langenbach, and T.M.G.J. van Eijden Fiber-type Composition of the Human Jaw Muscles--(Part 1) Origin and Functional Significance of Fiber-type Diversity J. Dent. Res., September 1, 2005; 84(9): 774 - 783. [Abstract] [Full Text] [PDF]

				J.A.M Korfage, J.H. Koolstra, G.E.J. Langenbach, and T.M.G.J. van Eijden Fiber-type Composition of the Human Jaw Muscles--(Part 2) Role of Hybrid Fibers and Factors Responsible for Inter-individual Variation J. Dent. Res., September 1, 2005; 84(9): 784 - 793. [Abstract] [Full Text] [PDF]