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J Dent Res 82(6): 428-432, 2003
© 2003 International and American Associations for Dental Research

RESEARCH REPORT
Clinical

Transforming Growth Factor-ß and Interleukin 10 in Oral Implant Sites in Humans

G. Schierano1, G. Bellone2, E. Cassarino1, M. Pagano3, G. Preti1,*, and G. Emanuelli2

1 Department of Prosthetic Dentistry,
2 Department of Clinical Physiopathology, and
3 Department of Biomedical Sciences and Human Oncology, University of Turin, Corso Dogliotti 14, 10126 Torino, Italy;

*corresponding author, giulio.preti{at}unito.it

Cross-talk between cells and cytokines in peri-implant tissue is largely unknown. The immune response in the gingival mucosa appears to favor implant integration over rejection, since titanium-implant-retained overdentures show long-term success. This study evaluates pro-inflammatory (interleukin [IL]-2, interferon [IFN]-{gamma}, IL-12) and anti-inflammatory (IL-4, IL-10, transforming growth factor [TGF]-ß1) cytokine mRNA expression and tissue morphometry in peri-implant soft tissue from patients before and during treatment with Brånemark titanium implants. Immediately after treatment with endosseous implant and overdenture, TGF-ß1 mRNA increased in peri-implant mucosa specimens; transcript accumulation for IL-10 was elevated at 4 months and decreased dramatically thereafter. Transcripts for IL-2, IFN-{gamma}, IL-12, and IL-4 were absent. Healthy osseointegrated implants showed no histological inflammation in most patients. These findings suggest that newly classified TGF-ß and/or IL-10 secreting T regulatory (r)/T helper (h)-3 cells may populate implant insertion sites.

KEY WORDS: Th1 • Th2 • Th3 • cytokines • oral implants






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