HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Services Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (7) Citing Articles via Google Scholar Google Scholar Articles by Yamaza, T. Articles by Tanaka, T. Search for Related Content PubMed PubMed Citation Articles by Yamaza, T. Articles by Tanaka, T.

NF-B Activation and iNOS Expression in the Synovial Membrane of Rat Temporomandibular Joints after Induced Synovitis

¹ Departments of Oral Anatomy and Cell Biology,
² Removable Prosthodontics, and
³ Orthodontics, Kyushu University Graduate School of Dental Science, Fukuoka 812-8582, Japan;

*corresponding author, yamazata{at}dent.kyushu-u.ac.jp

NF-B plays a pivotal role in pathogenesis in general arthritis. However, the participation of NF-B in inflammation of the temporomandibular joint (TMJ) is poorly understood. We examined NF-B expression in rat TMJs with synovitis induced by condyle hypermobility. By immunohistochemistry, NF-B immunoreactivity was found mainly in the cytoplasm, not the nucleus, of the synovial lining cells of induced-synovitis and control TMJs. Southwestern histochemistry, a new method for detecting transcription factors, showed greater NF-B expression in the nucleus of the synovial lining cells in the hypertrophic synovium than in control synovium. Increased numbers of the synovial lining cells with immunoreactivity for inducible nitric oxide synthase (iNOS), which is transcriptionally regulated by NF-B, were also seen in the inflamed synovium. These findings indicate that excess mechanical stress increases NF-B activation in the TMJ and suggest that active NF-B is involved in the progression of TMJ inflammation.

KEY WORDS: temporomandibular joint (TMJ) • synovitis • NF-B • iNOS • Southwestern histochemistry

This article has been cited by other articles:

				J. Ke, X. Long, Y. Liu, Y.F. Zhang, J. Li, W. Fang, and Q.G. Meng Role of NF-{kappa}B in TNF-{alpha}-induced COX-2 Expression in Synovial Fibroblasts from Human TMJ J. Dent. Res., April 1, 2007; 86(4): 363 - 367. [Abstract] [Full Text] [PDF]

				T. Yamaza, K.F. Masuda, I. Atsuta, K. Nishijima, M.A. Kido, and T. Tanaka Oxidative Stress-induced DNA Damage in the Synovial Cells of the Temporomandibular Joint in the Rat J. Dent. Res., August 1, 2004; 83(8): 619 - 624. [Abstract] [Full Text] [PDF]