HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Services Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (16) Citing Articles via Google Scholar Google Scholar Articles by Kohno, S. Articles by Tanne, K. Search for Related Content PubMed PubMed Citation Articles by Kohno, S. Articles by Tanne, K.

Expression of Vascular Endothelial Growth Factor and the Effects on Bone Remodeling during Experimental Tooth Movement

Department of Orthodontics, Hiroshima University Faculty of Dentistry, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan;

*corresponding author, mkaku{at}hiroshima-u.ac.jp

Vascular endothelial growth factor (VEGF) has an ability to induce functional osteoclasts as well as neovascularization. We recently reported that the number of osteoclasts was enhanced by the injection of recombinant human VEGF (rhVEGF) with the application of mechanical force for experimental tooth movement. In this study, the expression of VEGF was detected in osteoblasts on the tension side of the alveolar bone. Moreover, the rate of tooth movement was significantly increased in the rhVEGF injection groups compared with the controls. These results suggested that VEGF, highly expressed by mechanical stimuli, enhances the number of osteoclasts as a paracrine factor, and that the amount of tooth movement is accelerated by both endogenous VEGF and injected rhVEGF.

KEY WORDS: VEGF • osteoclast • osteoblast • bone remodeling • experimental tooth movement

This article has been cited by other articles:

				D.C. Wescott, M.N. Pinkerton, B.J. Gaffey, K.T. Beggs, T.J. Milne, and M.C. Meikle Osteogenic Gene Expression by Human Periodontal Ligament Cells under Cyclic Tension J. Dent. Res., December 1, 2007; 86(12): 1212 - 1216. [Abstract] [Full Text] [PDF]

				I. Andrade Jr., T.A. Silva, G.A.B. Silva, A.L. Teixeira, and M.M. Teixeira The Role of Tumor Necrosis Factor Receptor Type 1 in Orthodontic Tooth Movement J. Dent. Res., November 1, 2007; 86(11): 1089 - 1094. [Abstract] [Full Text] [PDF]

				J. Dai and A.B.M. Rabie VEGF: an Essential Mediator of Both Angiogenesis and Endochondral Ossification J. Dent. Res., October 1, 2007; 86(10): 937 - 950. [Abstract] [Full Text] [PDF]

				M. Motokawa, M. Kaku, Y. Tohma, T. Kawata, T. Fujita, S. Kohno, K. Tsutsui, J. Ohtani, K. Tenjo, M. Shigekawa, et al. Effects of Cyclic Tensile Forces on the Expression of Vascular Endothelial Growth Factor (VEGF) and Macrophage-colony-stimulating Factor (M-CSF) in Murine Osteoblastic MC3T3-E1 Cells J. Dent. Res., May 1, 2005; 84(5): 422 - 427. [Abstract] [Full Text] [PDF]

				H. Kanzaki, M. Chiba, I. Takahashi, N. Haruyama, M. Nishimura, and H. Mitani Local OPG Gene Transfer to Periodontal Tissue Inhibits Orthodontic Tooth Movement J. Dent. Res., December 1, 2004; 83(12): 920 - 925. [Abstract] [Full Text] [PDF]