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Proteome Analysis of Oral Pathogens

Institute of Dental Research, Westmead Centre for Oral Health, PO Box 533, Wentworthville, NSW 2145, Australia;

^* corresponding author, njacques{at}dental.wsahs.nsw.gov.au

The oral environment contains diverse communities of micro-organisms including bacteria, fungi, protozoa, and viruses. Studies of oral ecology have led to an appreciation of the complexity of the interactions that oral micro-organisms have with the host in both health and disease. Despite this, diseases such as dental caries and periodontal diseases are still worldwide human ailments, resulting in a high level of morbidity and an economic burden to society. Proteomics offers a new approach to the understanding of holistic changes occurring as oral micro-organisms adapt to environmental change within their habitats in the mouth.

KEY WORDS: proteomics • two-dimensional electrophoresis • MUDPIT • mass spectrometry • oral micro-organisms