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Fluoride Release from a Resin-modified Glass-ionomer Cement in a Continuous-flow System: Effect of pH

Paffenbarger Research Center, American Dental Association Foundation, National Institute of Standards and Technology, 100 Bureau Drive, Mail Stop 8546, Gaithersburg, MD 20899-8546, USA;

*corresponding author, Clif.Carey{at}NIST.Gov

Fluoride is added to many dental restorative materials, including glass-ionomer cements, for the specific purpose of leaching fluoride into the surrounding tissues to provide secondary caries inhibition. During the caries process, an acidic environment attacks the dental tissues as well as the glass-ionomer cement. We hypothesized that pH significantly affects the rate of release of fluoride from the glass-ionomer cement. A continuous-flow fluoride-measuring system that monitors the amount of fluoride released over time was used to determine the release of fluoride from a resin-modified glass-ionomer cement (KetacFil^®). The results show that the release rate began with a fast burst of fluoride which quickly diminished to low levels in 3 days. Under neutral pH conditions, the rate of fluoride release at 72 hrs was significantly slower than at pH 4.

KEY WORDS: fluoride • fluoride kinetics • glass-ionomer cement • fluoride release • controlled delivery systems

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