JDR JDR Most Cited Articles
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Data Supplement
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (11)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chesters, R.K.
Right arrow Articles by Mileriene, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chesters, R.K.
Right arrow Articles by Mileriene, J.
J Dent Res 81(9): 637-640, 2002
© 2002 International and American Associations for Dental Research

RESEARCH REPORT
Clinical

An Abbreviated Caries Clinical Trial Design Validated over 24 Months

R.K. Chesters1,*, N.B. Pitts2, G. Matuliene3, A. Kvedariene3, E. Huntington1, R. Bendinskaite3, I. Balciuniene3, J.R. Matheson1, J.A. Nicholson1, A. Gendvilyte3, R. Sabalaite3, J. Ramanauskiene3, D. Savage1, and J. Mileriene3

1 Unilever Dental Research, Port Sunlight, Quarry Road East, Bebington, Wirral CH63 3JW, UK;
2 Dundee University, Scotland; and
3 Vilnius University, Lithuania;

* corresponding author, Richard.Chesters{at}Unilever.com

Conventional caries trials last from 24 to 36 months. This study evaluated whether the previously established difference in efficacy between 1000- and 2500-ppm-fluoride dentifrices could be detected after 12 months. Caries was assessed by clinical visual assessment (CVA-simplified version of Dundee Selectable Threshold Method - DSTM), bitewing radiography, and Fiber Optic Transillumination (FOTI). Changes in status for individual surfaces were classified by means of pre-prepared matrices as 0 (unchanged), +1 (initiation or progression), or -1 (regression) and summed for each subject to yield an event score. Mean group event scores were calculated for each product. DSTM at the D1 [enamel and dentin] threshold showed significant inter-group differences in mean event scores (p < 0.003) and D1MFS increment (< 0.007) at 12 months; these were confirmed at 24 months by traditional increment analysis (CVA & FOTI at the D3 (dentin only) threshold + radiography, p < 0.03). This study confirms the validity of an abbreviated trial protocol.

KEY WORDS: caries clinical trials • fiber optic transillumination • clinical visual assessment • Dundee Selectable Threshold Method • digital radiography




This article has been cited by other articles:


Home page
 J. Dent. Res.Home page
J.W. Stamm
The Classic Caries Clinical Trial: Constraints and Opportunities
J. Dent. Res., July 1, 2004; 83(suppl_1): C6 - C14.
[Full Text] [PDF]

Home page
 J. Dent. Res.Home page
B.P. Katz and E. Huntington
Statistical Issues for Combining Multiple Caries Diagnostics for Demonstrating Caries Efficacy
J. Dent. Res., July 1, 2004; 83(suppl_1): C109 - C112.
[Abstract] [Full Text] [PDF]

Home page
 J. Dent. Res.Home page
R.K. Chesters, R.P. Ellwood, A.R. Biesbrock, and S.R. Smith
Potential Modern Alternative Designs for Caries Clinical Trials (CCTs) and How These can be Validated against the Conventional Model
J. Dent. Res., July 1, 2004; 83(suppl_1): C122 - C124.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
IADR Journals Advances in Dental Research ®
Journal of Dental Research ® Critical Reviews (1990-2004)
Copyright © 2002 Institutional Access Guidelines