HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Services Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (5) Citing Articles via Google Scholar Google Scholar Articles by Haruyama, N. Articles by Mitani, H. Search for Related Content PubMed PubMed Citation Articles by Haruyama, N. Articles by Mitani, H.

Estrous-cycle-dependent Variation in Orthodontic Tooth Movement

¹ Division of Orthodontics, Department of Life-Long Oral Health Science, and
² Division of Pharmacology, Department of Oral Biology, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan;

*corresponding author, igarashi{at}mail.cc.tohoku.ac.jp

Sex hormones, including estradiol, play important physiological roles in bone metabolism. The purpose of this study was to investigate whether there is estrous-cycle-dependent variation in orthodontic tooth movement, and, if so, to determine the mechanism. Ten-week-old female Wistar rats were used. They received repeated orthodontic force during specific phases in the estrous cycle. Tooth movement in animals that received force principally in estrus was about 33% greater than that in animals that received such force principally in pro-estrus (p < 0.05). Serum estradiol levels also varied according to the estrous cycle, with a peak during pro-estrus and a nadir during estrus, and were inversely related to tooth movement. Furthermore, there were negative correlations between estradiol and both serum TRAP activity and pyridinoline (r = -0.42, p < 0.05; r = -0.59, p < 0.001). These results suggest that cyclic changes in the estradiol level may be associated with the estrous-cycle-dependent variation in tooth movement through its effects on bone resorption.

KEY WORDS: estrous cycle • tooth movement • sex hormones • bone metabolic markers • rat

This article has been cited by other articles:

				J.K. Hartsfield Jr., E.T. Everett, and R.A. Al-Qawasmi GENETIC FACTORS IN EXTERNAL APICAL ROOT RESORPTION AND ORTHODONTIC TREATMENT Crit. Rev. Oral. Biol. Med., March 1, 2004; 15(2): 115 - 122. [Abstract] [Full Text]