| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
RESEARCH REPORT |
1 Department of Periodontology, School of Dentistry,
2 Department of Thoracic and Cardiovascular Surgery, School of Medicine,
3 Department of Molecular Biology, College of Natural Sciences, and
4 Department of Pharmacology, School of Medicine, Pusan National University, 1-10, Ami-Dong, Seo-Ku, Pusan 602-739, Korea;
*corresponding author, jilchoi{at}pusan.ac.kr
Human atherosclerotic plaques contain heat-shock proteins which may serve as potential targets of the immune response in atherosclerosis. Since periodontal infections are suggested as risk factors for the development of cardiovascular diseases, we undertook the present study to evaluate the T-cell immune responses specific to Porphyromonas gingivalis (P. gingivalis) heat-shock protein (hsp)60 in patients suffering from atherosclerosis. Anti-P. gingivalis hsp60 IgG antibody titers were elevated in all patients. We could establish P. gingivalis hsp-specific T-cell lines from the atheroma lesions and the peripheral blood. The T-cell lines were a mixture of CD4+ and CD8+ cells producing the cytokines characteristic of both Th1 and Th2 subsets. The present findings suggest that the T-cell immune response specific to P. gingivalis hsp60 may be involved in the immunopathologic process of atherosclerotic diseases.
KEY WORDS: Porphyromonas gingivalis • heat-shock protein • periodontal pathogen • atherosclerosis • T-cell line
This article has been cited by other articles:
|
|
 |
|
  T. T. Keller, J. J. van der Meer, P. Teeling, K. van der Sluijs, M. M. Idu, G. F. Rimmelzwaan, M. Levi, A. C. van der Wal, and O. J. de Boer Selective Expansion of Influenza A Virus-Specific T Cells in Symptomatic Human Carotid Artery Atherosclerotic Plaques Stroke, January 1, 2008; 39(1): 174 - 179. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.-K. L. Robertson and G. K Hansson T Cells in Atherogenesis: For Better or For Worse? Arterioscler. Thromb. Vasc. Biol., November 1, 2006; 26(11): 2421 - 2432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Zschenker, T. Illies, and D. Ameis Overexpression of lysosomal Acid lipase and other proteins in atherosclerosis. J. Biochem., July 1, 2006; 140(1): 23 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-J. Janket, J. H. Meurman, P. Nuutinen, M. Qvarnstrom, M. E. Nunn, A. E. Baird, T. E. Van Dyke, and J. A. Jones Letter to the Editor: Salivary Lysozyme and Prevalent Coronary Heart Disease. Possible Effects of Oral Health on Endothelial Dysfunction Arterioscler. Thromb. Vasc. Biol., February 1, 2006; 26(2): 433 - 434. [Full Text] [PDF]
|
|
|
|
 |
|
 B.A. Taylor, G.H. Tofler, H.M.R. Carey, M.-C. Morel-Kopp, S. Philcox, T.R. Carter, M.J. Elliott, A.D. Kull, C. Ward, and K. Schenck Full-mouth Tooth Extraction Lowers Systemic Inflammatory and Thrombotic Markers of Cardiovascular Risk J. Dent. Res., January 1, 2006; 85(1): 74 - 78. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. V. Kozarov, B. R. Dorn, C. E. Shelburne, W. A. Dunn Jr, and A. Progulske-Fox Human Atherosclerotic Plaque Contains Viable Invasive Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis Arterioscler. Thromb. Vasc. Biol., March 1, 2005; 25(3): e17 - e18. [Full Text] [PDF]
|
|
|
|
 |
|
 P. Ford, E. Gemmell, P. Walker, M. West, M. Cullinan, and G. Seymour Characterization of Heat Shock Protein-Specific T Cells in Atherosclerosis Clin. Vaccine Immunol., February 1, 2005; 12(2): 259 - 267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-I. Choi, S.-W. Chung, H.-S. Kang, B.Y. Rhim, Y.-M. Park, U.-S. Kim, and S.-J. Kim Epitope Mapping of Porphyromonas gingivalis Heat-shock Protein and Human Heat-shock Protein in Human Atherosclerosis J. Dent. Res., December 1, 2004; 83(12): 936 - 940. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Meurman, M. Sanz, and S.-J. Janket ORAL HEALTH, ATHEROSCLEROSIS, AND CARDIOVASCULAR DISEASE Crit. Rev. Oral. Biol. Med., November 1, 2004; 15(6): 403 - 413. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-J. Janket, M. Qvarnstrom, J. H. Meurman, A. E. Baird, P. Nuutinen, and J. A. Jones Asymptotic Dental Score and Prevalent Coronary Heart Disease Circulation, March 9, 2004; 109(9): 1095 - 1100. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. J de Boer, A. E Becker, and A. C van der Wal T lymphocytes in atherogenesis--functional aspects and antigenic repertoire Cardiovasc Res, October 15, 2003; 60(1): 78 - 86. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| IADR Journals | Advances in Dental Research ® |
| Journal of Dental Research ® | Critical Reviews (1990-2004) |
