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Components of Dentinal Adhesives Modulate Heat Shock Protein 72 Expression in Heat-stressed THP-1 Human Monocytes at Sublethal Concentrations

¹ Department of Oral Health Science, Graduate School of Dental Medicine, Hokkaido University Graduate School of Dental Medicine, Kita 13, Nishi 7, Kita-ku, Sapporo 060-8586, Japan;
² Department of Oral Rehabilitation, Medical College of Georgia, Augusta, GA 30912-1260; and
³ Department of Oral Functional Science, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan;

*corresponding author, nodam{at}den.hokudai.ac.jp

Few studies have investigated the ability of dental resins to induce cellular stress at sublethal concentrations. Cellular stress, especially in immune cells such as monocytes, may modulate the biological response to materials or the host's ability to respond to bacterially mediated inflammation. The current study examined the ability of sublethal concentrations of 2-hydroxylethylmethacrylate (HEMA) and triethyleneglycol dimethacrylate (TEGDMA) to induce heat shock protein 72 (HSP72) in human monocytes. HEMA and TEGDMA significantly suppressed heat-induced HSP72 expression, even at sublethal levels, but did not induce HSP72 by themselves. The results of the current study suggest that components released from dental resin could modulate the HSP stress response without altering cellular metabolic activity.

KEY WORDS: dental adhesive • monomers • cell stress

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