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DNA Hybridization Arrays for Gene Expression Analysis of Human Oral Cancer

¹ Laboratory of Oral & Maxillofacial Surgery, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, and Massachusetts General Hospital, 1 Fruit Street, Boston, MA 02114; and
² Laboratory of Molecular Pathology, Division of Oral Pathology, Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, Boston, MA 02115;

*corresponding author, 188 Longwood Avenue, Boston, MA 02115, randy_todd{at}hms.harvard.edu

DNA hybridization arrays permit global gene expression profiling to be done in a single experiment. The evolution and challenges of DNA hybridization arrays are reflected in the variety of experimental platforms, probe composition, hybridization/signal detection methods, and bioinformatic interpretation. In tumor biology, DNA hybridization arrays are being used for gene/gene pathway discovery, diagnosis, and therapeutic design. Similar applications are advancing our understanding of oral cancer cell biology.

KEY WORDS: microarray • gene expression • oral cancer

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