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Spatial Distribution of Myosin Heavy-chain Isoforms in Mouse Masseter

Dept. of Orthodontics, Box 100444, JHMHSC, University of Florida, Gainesville, FL 32610-0444;

*corresponding author, widmer{at}dental.ufl.edu

There is a paucity of information regarding the anatomy and muscle fiber phenotype of the masseter. The objective of this study was to characterize the distribution of each myosin heavy-chain (MyHC) isoform within different anatomical regions of male and female mouse masseters. Masseters from male and female CD-1 mice (2-4 months old) were examined for description of the anatomical partitioning of muscle fibers and endplate distribution. The spatial distribution of MyHC isoforms—embryonic, neonatal, slow, -cardiac, IIa, and IIb—was determined within the defined masseter partitions by means of Western blot analysis and immunofluorescent localization. Types IIa, IIx, and IIb were the predominant MyHC isoforms observed. Distinct differences in the spatial distribution of these MyHC isoforms were found between muscle regions and varied between sexes. The regionalization of muscle fiber types in the mouse masseter is consistent with the functional compartmentalization of the masseter observed in other species.

KEY WORDS: masseter • mouse • myosin heavy-chain • sexual dimorphism • muscle partition