Journal of Dental Research, Vol 80, 1412-1415, Copyright © 2001 by International & American Associations for Dental Research Online Journals

ARTICLES

Distribution and excretion of TEGDMA in guinea pigs and mice

F. X. Reichl, J. Durner, R. Hickel, K. H. Kunzelmann, A. Jewett, M. Y. Wang, W. Spahl, H. Kreppel, G. W. Moes, K. Kehe, U. Walther, W. Forth and W. R. Hume
Walther-Straub-Institute of Pharmacology and Toxicology, Ludwig-Maximilians-University of Munich, Germany.

The monomer triethyleneglycoldimethacrylate (TEGDMA) is used as a diluent in many resin-based dental materials. It was previously shown in vitro that TEGDMA was released into the adjacent biophase from such materials during the first days after placement. In this study, the uptake, distribution, and excretion of 14C-TEGDMA applied via gastric, intradermal, and intravenous administration at dose levels well above those encountered in dental care were examined in vivo in guinea pigs and mice as a test of the hypothesis that TEGDMA reaches cytotoxic levels in mammalian tissues. 14C-TEGDMA was taken up rapidly from the stomach and small intestine after gastric administration in both species and was widely distributed in the body following administration by each route. Most 14C was excreted within one day as 14CO2. The peak equivalent TEGDMA levels in all mouse and guinea pig tissues examined were at least 1000-fold less than known toxic levels. The study therefore did not support the hypothesis.

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