Journal of Dental Research, Vol 80, 2005-2010, Copyright © 2001 by International & American Associations for Dental Research Online Journals

ARTICLES

The association of bacterial adhesion with dental caries

C. Stenudd, A. Nordlund, M. Ryberg, I. Johansson, C. Kallestal and N. Stromberg
Department of Odontology/Cariology, Umea University, Sweden.

Saliva adhesion of bacteria is a key event in oral biofilm formation. Here, we used partial least-squares (PLS) analysis to correlate adhesion of cariogenic (Streptococcus mutans Ingbritt) and commensal (Actinomyces naeslundii LY7) model bacteria, and their agglutinin and acidic proline-rich protein ligands, respectively, with high and low caries experiences in 38 children reflecting today's skewed caries distribution. Adhesion of S. mutans was among the factors correlating strongest with high caries experience when PLS modeled together with traditional factors (e.g., sugar intake, lactobacilli counts). Saliva phenotypes with high agglutinin levels and Db-s (an acidic PRP variant) coincided with both high caries experience and S. mutans adhesion. A. naeslundii adhesion correlated with low caries experience. Non-Db phenotypes (i.e., acidic PRP-1 and PRP-2 variants) coincided with both low caries experience and S. mutans, but high A. naeslundii, adhesion. Thus, bacterial adhesion may modulate susceptibility and resistance to dental caries.

This article has been cited by other articles:

				G.M. Zakhary, R.M. Clark, S.I. Bidichandani, W.L. Owen, R.L. Slayton, and M. Levine Acidic Proline-rich Protein Db and Caries in Young Children J. Dent. Res., December 1, 2007; 86(12): 1176 - 1180. [Abstract] [Full Text] [PDF]

				M. Drobni, T. Li, C. Kruger, V. Loimaranta, M. Kilian, L. Hammarstrom, H. Jornvall, T. Bergman, and N. Stromberg Host-Derived Pentapeptide Affecting Adhesion, Proliferation, and Local pH in Biofilm Communities Composed of Streptococcus and Actinomyces Species Infect. Immun., November 1, 2006; 74(11): 6293 - 6299. [Abstract] [Full Text] [PDF]

				M. Drobni, I.-M. Olsson, C. Eriksson, F. Almqvist, and N. Stromberg Multivariate Design and Evaluation of a Set of RGRPQ-derived Innate Immunity Peptides J. Biol. Chem., June 2, 2006; 281(22): 15164 - 15171. [Abstract] [Full Text] [PDF]

				R.P. Allaker and D. Dymock Proceedings of the 8th European Oral Microbiology Workshop Adv. Dent. Res., November 1, 2005; 18(2): 27 - 33. [Full Text] [PDF]

				M. Levine, W. L. Owen, and K. T. Avery Antibody Response to Actinomyces Antigen and Dental Caries Experience: Implications for Caries Susceptibility Clin. Vaccine Immunol., June 1, 2005; 12(6): 764 - 769. [Abstract] [Full Text] [PDF]

				V. Loimaranta, N. S. Jakubovics, J. Hytonen, J. Finne, H. F. Jenkinson, and N. Stromberg Fluid- or Surface-Phase Human Salivary Scavenger Protein gp340 Exposes Different Bacterial Recognition Properties Infect. Immun., April 1, 2005; 73(4): 2245 - 2252. [Abstract] [Full Text] [PDF]

				T. Oho, F. J. Bikker, A. V. Nieuw Amerongen, and J. Groenink A Peptide Domain of Bovine Milk Lactoferrin Inhibits the Interaction between Streptococcal Surface Protein Antigen and a Salivary Agglutinin Peptide Domain Infect. Immun., October 1, 2004; 72(10): 6181 - 6184. [Abstract] [Full Text] [PDF]

				F. J. Bikker, A. J. M. Ligtenberg, K. Nazmi, E. C. I. Veerman, W. van't Hof, J. G. M. Bolscher, A. Poustka, A. V. N. Amerongen, and J. Mollenhauer Identification of the Bacteria-binding Peptide Domain on Salivary Agglutinin (gp-340/DMBT1), a Member of the Scavenger Receptor Cysteine-rich Superfamily J. Biol. Chem., August 23, 2002; 277(35): 32109 - 32115. [Abstract] [Full Text] [PDF]