JDR JDR Most Cited Articles
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hodge, P. J.
Right arrow Articles by Kinane, D. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hodge, P. J.
Right arrow Articles by Kinane, D. F.

Journal of Dental Research, Vol 79, 857-863, Copyright © 2000 by International & American Associations for Dental Research Online Journals

ARTICLES

Clinical and genetic analysis of a large North European Caucasian family affected by early-onset periodontitis

P. J. Hodge, P. W. Teague, A. F. Wright and D. F. Kinane
Department of Periodontics, University of Glasgow Dental School, UK. pjh@hodgeqc.freeserve.co.uk

Genetic studies of early-onset periodontitis (EOP) are hampered by several factors. These include delayed onset of the trait, an upper age limit of expression of the disease, and lack of phenotypic information for edentulous family members. Segregation analyses of families with EOP support a major locus hypothesis but fail to define clearly the criteria used for diagnosis of the relatives. Confirmation of a proposed mode of inheritance and the identification of risk genes is awaited by means of family linkage studies. It is suggested that a system can be developed for the current and retrospective diagnosis of relatives of EOP probands. In addition, it is hypothesized that the large family presented here is suitable for a linkage study. Relatives of the proband who were unavailable for a full periodontal examination, were edentulous, or were deceased, were diagnosed by means of documented clinical evidence of periodontal disease or from reported case histories. Segregation analysis was performed. Analysis of the power of the pedigree to detect linkage was carried out by means of the SIMLINK program. Three different categories were defined according to the reliability of diagnosis of EOP. Segregation analysis indicated either autosomal-dominant or X-linked-dominant inheritance in this family. The simulations showed lod scores above 3.0 for all locations of the disease gene, and for each category of diagnosis. In conclusion, a method has been developed which can be used for the diagnosis of relatives of EOP probands when ideal clinical data are unavailable. The simulations suggest that this family is suitable for a genetic linkage study with the aim of identifying the location of one or more susceptibility genes.


This article has been cited by other articles:


Home page
 Crit. Rev. Oral Biol. Med.Home page
D.F. Kinane and T.C. Hart
GENES AND GENE POLYMORPHISMS ASSOCIATED WITH PERIODONTAL DISEASE
Crit. Rev. Oral. Biol. Med., November 1, 2003; 14(6): 430 - 449.
[Abstract] [Full Text] [PDF]

Home page
 Crit. Rev. Oral Biol. Med.Home page
K. Iida and I. Nishimura
GENE EXPRESSION PROFILING BY DNA MICROARRAY TECHNOLOGY
Crit. Rev. Oral. Biol. Med., January 1, 2002; 13(1): 35 - 50.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
IADR Journals Advances in Dental Research ®
Journal of Dental Research ® Critical Reviews (1990-2004)
Copyright © 2000 Institutional Access Guidelines