JDR JDR Most Cited Articles
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yamashiro, T.
Right arrow Articles by Takada, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yamashiro, T.
Right arrow Articles by Takada, K.

Journal of Dental Research, Vol 77, 1920-1925, Copyright © 1998 by International & American Associations for Dental Research Online Journals

ARTICLES

Expression of Fos in the rat forebrain following experimental tooth movement

T. Yamashiro, K. Satoh, K. Nakagawa, H. Moriyama, T. Yagi and K. Takada
Department of Orthodontics, Okayama University Dental School, Japan.

Orthodontic tooth movement is known to cause pain and discomfort to patients. Mechanically induced inflammatory responses in the periodontium are assumed to be related to the mechanism of pain sensation. An immediate-early gene, c-fos, that is expressed within some neurons following synaptic activation, is widely used as a marker for neuronal activity following noxious or innocuous stimulation. We have recently demonstrated that experimental tooth movement produced Fos induction in the ipsilateral trigeminal subnucleus caudalis and in the bilateral lateral parabrachial nucleus, which is known to be involved in the transmission of nociceptive information. As a further step, we investigated the distribution of Fos-like immunoreactive neurons in the upper brain regions. Twenty-four hours after the commencement of the experimental tooth movement, the Fos-like immunoreactive neurons appeared in the central nucleus of the amygdala (Ce), paraventricular nucleus of the hypothalamus (PVH), and paraventricular nucleus of the thalamus (PV) of the experimental rats. The numbers of the labeled neurons were significantly increased by 639% (P < 0.001) and 644% (P < 0.001) in the ipsilateral and contralateral sides of the Ce, respectively, by 292% (P < 0.001) and 307% (P < 0.001) in the ipsilateral and contralateral sides of the PVH, and by 264% (P < 0.0001) in the PV with respect to sham control rats. These results suggest that nociceptive information caused by experimental tooth movement might be transmitted and modulated in several regions of the forebrain.


This article has been cited by other articles:


Home page
 Eur J OrthodHome page
V. Krishnan
Orthodontic pain: from causes to management--a review
Eur J Orthod, April 1, 2007; 29(2): 170 - 179.
[Abstract] [Full Text] [PDF]

Home page
 J. Dent. Res.Home page
C.M. Magdalena, V.P. Navarro, D.M. Park, M.B.S. Stuani, and M.J.A. Rocha
c-fos Expression in Rat Brain Nuclei Following Incisor Tooth Movement
J. Dent. Res., January 1, 2004; 83(1): 50 - 54.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
IADR Journals Advances in Dental Research ®
Journal of Dental Research ® Critical Reviews (1990-2004)
Copyright © 1998 Institutional Access Guidelines