JDR Woodhead Publishing
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sims, M. R.
Right arrow Articles by Dreyer, C. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sims, M. R.
Right arrow Articles by Dreyer, C. W.

Journal of Dental Research, Vol 75, 1503-1511, Copyright © 1996 by International & American Associations for Dental Research Online Journals

ARTICLES

Microvascular luminal volume changes in aged mouse periodontal ligament

M. R. Sims, P. I. Leppard, W. J. Sampson and C. W. Dreyer
Faculty of Dentistry, University of Sydney, N.S.W., Australia.

Data for the microvascular bed in the aged periodontal ligament have not been established. This investigation tested the hypothesis that the luminal microvascular volume decreased in the aged ligament. Mice 35 days old and one year old were vascular-perfused and the mandibular first molar periodontal ligament processed for electron microscopy. Tissue quadrats from each circumferential third ligament region were recorded at 150-microns intervals from the alveolar crest to the apex for randomized sampling of blood vessel lumina. The data were analyzed with a generalized linear model at the p < 0.01 level for the interaction of the aging effect with differences across regions. Stereological parameters were established for vessel lumen volume, and for surface and length densities. Mean ligament width decreased from 119.9 +/- 16.94 (micron +/- SE) in young mice to 60.0 +/- 10.58 (micron +/- SE) in aged mice. The luminal volume of 8.63 +/- 1.37 (% +/- SE) in young ligament increased to 9.83 +/- 2.14 (% +/- SE) in aged ligament. Collecting venules and the combined group of arterio-venous anastomoses with terminal arterioles showed a two-fold increase in luminal volume density (p < 0.01). In aged ligament, regional shifts affected the microvascular bed distribution, but these changes were not consistent across regions, or with depth. The average cross-sectional tissue area served per capillary decreased from 2117 microns 2 to 1451 microns 2 for young and old. Average ligament thickness served per capillary dropped from 52.5 microns to 27.5 microns. These reductions in average diffusion distances indicated a change in the quality of the diffusion barrier with age.


This article has been cited by other articles:


Home page
 J. Bacteriol.Home page
Y.-H. Li, M. N. Hanna, G. Svensater, R. P. Ellen, and D. G. Cvitkovitch
Cell Density Modulates Acid Adaptation in Streptococcus mutans: Implications for Survival in Biofilms
J. Bacteriol., December 1, 2001; 183(23): 6875 - 6884.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
IADR Journals Advances in Dental Research ®
Journal of Dental Research ® Critical Reviews (1990-2004)
Copyright © 1996 Institutional Access Guidelines