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Journal of Dental Research, Vol 75, 581-587, Copyright © 1996 by International & American Associations for Dental Research Online Journals

ARTICLES

Immunoreactivity of tenascin-C in dentin matrix in dentinogenesis imperfecta associated with osteogenesis imperfecta

P. L. Lukinmaa, G. Allemanni, J. Waltimo and L. Zardi
Department of Oral Pathology, University of Helsinki, Finland.

Osteogenesis imperfecta (OI) is a heterogeneous group of heritable connective tissue disorders, assigned to different mutations in type I collagen genes. A variety of structural abnormalities of dentin have been described in dentinogenesis imperfecta (DI) associated with OI. To clarify further the constitution of the dentin matrix in OI, we immunostained frozen and paraffin sections of deciduous teeth from four patients, each from a different family, with two monoclonal antibodies (MAbs) to the matrix glycoprotein tenascin-C (TN-C). One of the MAbs recognizes an epitope common to all TN-C isoforms (BC-4), and the other is specific for a splicing variant (BC-2). Normal teeth, oral mucosa, and skin were analyzed for comparison. Staining patterns with the two MAbs did not differ markedly. Normal dentin matrix and odontoblasts were lacking reactivity, but the pulp stained clearly. TN-C reactivity was present in the dentin matrix of all teeth obtained from two patients with different OI phenotypes and DI, and in one out of three teeth from one patient who also had DI. The reactivity was distributed in layers, but the staining patterns varied from one patient to another and from tooth to tooth. Intratubular staining seen in a tooth from the patient with clinically and histologically normal teeth was comparable with that present in normal deciduous teeth. The variation in TN-C expression suggests that, besides genetic heterogeneity, epigenetic factors could influence the composition of the dentin matrix in OI.


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L. Häkkinen, H. C. Hildebrand, A. Berndt, H. Kosmehl, and H. Larjava
Immunolocalization of Tenascin-C, {alpha}9 Integrin Subunit, and {alpha}v{beta}6 Integrin During Wound Healing in Human Oral Mucosa
J. Histochem. Cytochem., July 1, 2000; 48(7): 985 - 998.
[Abstract] [Full Text]


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