Journal of Dental Research, Vol 71, 1577-1581, Copyright © 1992 by International & American Associations for Dental Research Online Journals
Inhibition of plaque formation and gingivitis in beagle dogs by topical use of a degradable controlled-release system containing chlorhexidine
A. Kozlovsky, A. Sintov, Y. Zubery and H. Tal
Department of Periodontology, Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Israel.
The in vivo efficacy of a newly-developed dental application of a
film-forming, chlorhexidine-containing system was examined in beagle dogs.
A self-disintegrating film-forming solution was applied three times weekly
to the dentitions of 7 out of 13 dogs, which were fed a soft-food diet.
Plaque accumulation (Plaque Index) and gingival inflammation (Gingival
Index) were recorded at one, two, four, six, and eight weeks. The local
delivery of low-dose chlorhexidine to dogs significantly inhibited
gingivitis and plaque formation. It is concluded that the dental
application of a film-forming system may be a preferable method of
periodontal disease prophylaxis, and may enhance supragingival plaque
control in areas of isolated periodontal problems associated with obvious
local predisposing factors.
