Journal of Dental Research, Vol 71, 448-452, Copyright © 1992 by International & American Associations for Dental Research Online Journals

ARTICLES

In vivo fluoride concentrations measured for two hours after a NaF or a novel two-solution rinse

G. L. Vogel, Y. Mao, C. M. Carey, L. C. Chow and S. Takagi
American Dental Association Health Foundation, Paffenbarger Research Center, National Institute of Standard Technology, Gaithersburg, Maryland 20899.

The concentrations of fluoride in various samples from the oral environment were measured at timed intervals after a novel rinse or a NaF rinse, both containing a total of 12 mmol/L (228 ppm) fluoride. The novel rinse consisted of two solutions mixed just before application: Part A contained calcium chloride and sodium acetate; part B contained a hydrolyzable source of fluoride (sodium hexafluorosilicate) and sodium phosphate. Samples were obtained as follows: Single-site plaque-fluid samples were obtained by centrifugation of first-molar plaque; pooled whole-plaque samples were collected from second molars; centrifuged, pooled whole-saliva was collected by vacuum. All samples were analyzed by micro-analytical methods. Results showed that, compared with NaF, the two-solution rinse produced significantly higher salivary fluoride concentrations, plaque-fluid fluoride concentrations, and acid-extractable fluoride in the whole plaque by factors of about 4, 2, and 6, respectively, at 120 min. The results of this study suggest that the new rinse may provide a greater cariostatic effect at the same fluoride dosage than does a NaF rinse.

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				G.L. Vogel, G.E. Schumacher, L.C. Chow, S. Takagi, and C.M. Carey Ca Pre-rinse Greatly Increases Plaque and Plaque Fluid F J. Dent. Res., May 1, 2008; 87(5): 466 - 469. [Abstract] [Full Text] [PDF]