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Journal of Dental Research, Vol 70, 1306-1308, Copyright © 1991 by International & American Associations for Dental Research Online Journals

ARTICLES

Effect of a beta-adrenergic blocking agent on dental anxiety

H. H. Liu, P. Milgrom and L. Fiset
Faculty of Dentistry, National University of Singapore.

The effect of propranolol was studied on 23 dental phobics in a double-blind, placebo-controlled clinical trial involving actual dental treatment. The subjects were selected because they showed high physiological reactivity in the dental situation. Twelve subjects received the test drug and 11 subjects received the placebo at individualized doses of either 80 or 120 mg. A significant difference in self-reported anxiety at the injection phase of treatment and less overall pain intensity and aversiveness were observed for the propranolol as compared with the placebo group. No differences were detected for behavior ratings. Beta-adrenergic blocking agents may have utility for reducing anxiety in individuals fearful of dental treatment.




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