Journal of Dental Research, Vol 70, 948-951, Copyright © 1991 by International & American Associations for Dental Research Online Journals
A comparative study of fluoride pharmacokinetics in five species
G. M. Whitford, E. D. Biles and N. L. Birdsong-Whitford
Department of Oral Biology, Medical College of Georgia, Augusta 30912-1129.
This study was designed to quantitate and compare the major features of the
short-term pharmacokinetics of fluoride--i.e., the plasma (Cp), renal (Cr),
and extra-renal (Cer) clearances--in young adult dogs, cats, rabbits, rats,
and hamsters. Plasma and urine samples were collected for seven h after the
iv administration of fluoride (0.5 mg F/kg). Cp ranged from 3.5 to 8.6
mL/min/kg in the dog and hamster, respectively. Cr ranged from less than
1.5 mL/min/kg in the dog and rabbit to about 3.5 mL/min/kg in the rat and
hamster. Cer ranged from 2.1 mL/min/kg in the dog to over 4.5 mL/min/kg in
the cat, rabbit, and hamster. It was concluded that (1) there are major
quantitative differences in the metabolic handling of fluoride among the
five species, and that (2) Cp, Cr, and Cer values of the young adult dog,
when factored for body weight, resemble those of the young adult human most
closely.
