Journal of Dental Research, Vol 70, 162-166, Copyright © 1991 by International & American Associations for Dental Research Online Journals

ARTICLES

Protection of rats against dental caries by passive immunization with hen-egg-yolk antibody (IgY)

S. Otake, Y. Nishihara, M. Makimura, H. Hatta, M. Kim, T. Yamamoto and M. Hirasawa
Department of Clinical Pathology, Nihon University School of Dentistry, Chiba, Japan.

Hen-egg-yolk antibody (IgY) was prepared against Streptococcus mutans MT8148 serotype c that was cultivated in medium containing sucrose, and it was used in passive caries-immunity studies. Specific pathogen-free rats infected with S. mutans MT8148 (c) and fed with a cariogenic diet containing more than 2% immune yolk powder developed significantly lower caries scores than did the ones infected with the same strain and fed with a diet containing only control yolk powder obtained from non-immunized hens. Similar results were obtained in an experiment with rats infected with S. mutans JC-2 (c) strain. Rats provided a diet supplemented with 0.5% immune water-soluble protein fraction containing S. mutans-specific IgY and challenged with S. mutans MT8148 exhibited significantly fewer caries lesions, compared with control rats on the normal diet.

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