Journal of Dental Research, Vol 70, 1320-1327, Copyright © 1991 by International & American Associations for Dental Research Online Journals

ARTICLES

Age-related changes in mucins from human whole saliva

P. C. Denny, P. A. Denny, D. K. Klauser, S. H. Hong, M. Navazesh and L. A. Tabak
Department of Basic Sciences, School of Dentistry, University of Southern California, Los Angeles 90089-0641.

The predominant mucins in human whole saliva, MG1 and MG2, serve to protect and to lubricate the oral cavity. In this study, both unstimulated and stimulated whole salivas were collected from two groups of subjects: young (18-35 years of age) and aged (65-83 years of age). The subjects were in apparent good health. Saliva samples from each subject were analyzed by SDS-PAGE. The gels were stained with Stains-all, and both MG1 and MG2 were quantitated by video-image densitometry. The protocol gave reproducible values for each mucin. The stimulated and unstimulated salivas from aged subjects showed significant reductions in concentrations of both MG1 and MG2, as quantitated in mucin dye-binding units. Possible associations of these reductions with the aging process are discussed.

This article has been cited by other articles:

				L. Li, S. Redding, and A. Dongari-Bagtzoglou Candida glabrata, an Emerging Oral Opportunistic Pathogen J. Dent. Res., March 1, 2007; 86(3): 204 - 215. [Abstract] [Full Text] [PDF]

				M.-A. Peyron, O. Blanc, J. P. Lund, and A. Woda Influence of Age on Adaptability of Human Mastication J Neurophysiol, August 1, 2004; 92(2): 773 - 779. [Abstract] [Full Text] [PDF]

				K. A. Thomsson, A. Prakobphol, H. Leffler, M. S. Reddy, M. J. Levine, S. J. Fisher, and G. C. Hansson The salivary mucin MG1 (MUC5B) carries a repertoire of unique oligosaccharides that is large and diverse Glycobiology, January 1, 2002; 12(1): 1 - 14. [Abstract] [Full Text] [PDF]