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Journal of Dental Research, Vol 69, 909-912, Copyright © 1990 by International & American Associations for Dental Research Online Journals

ARTICLES

Properties of alkaline phosphatase of the human dental pulp

M. Goseki, S. Oida, A. Nifuji and S. Sasaki
Department of Biochemistry, Tokyo Medical and Dental University, Japan.

Enzymatic and immunological properties of alkaline phosphatase [ALP; orthophosphoric monoester phosphohydrolase, alkaline optimum, EC 3.1.3.1.] in the human dental pulp were investigated. In inhibition and thermal inactivation studies, dental pulp ALP showed properties of universal-type ALP (kidney/bone/liver type). Dental pulp ALP cross-reacted with polyclonal and monoclonal antibodies against purified swine-kidney ALP, and with monoclonal antibody against ALP of human osteoblast-like cells in the same manner as ALPs of human bone and kidney. The sodium dodecyl sulfate-gel electrophoretic pattern showed a 140,000-Mr native protein band. These data suggest that dental pulp ALP can be classified as a universal-type ALP having antigenic determinants common to ALP of the kidney and bone.




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