Journal of Dental Research, Vol 69, 906-908, Copyright © 1990 by International & American Associations for Dental Research Online Journals
Depressed eruption rate of the rat maxillary incisor in a drug-induced uncompensated hemolytic state model
M. J. Giglio, A. M. Sanz and C. E. Bozzini
Department of Physiology, University of Buenos Aires, Faculty of Dentistry, Argentina.
Female rats weighing about 180 g were separated into two groups. One group
(A) received phenylhydrazine (PHZ) every other day during three weeks (for
induction of an uncompensated hemolytic state), while the control group (C)
received saline. The evidence for the establishment of the uncompensated
hemolytic state was obtained by hematocrit value, reticulocyte count, and
red-cell-volume-59Fe uptake. Body-weight gain (which is a measure of
overall body growth rate), body-length gain (which is a measure of
longitudinal skeletal growth rate), food intake, and maxillary incisor
eruption rate (ER) were significantly depressed in rats of group A during
the PHZ-injection period, in relation to rats of group C. These results
indicate that anemia and/or associated factors depress ER, along with body
growth and skeletal growth.
