Journal of Dental Research, Vol 69, 454-457, Copyright © 1990 by International & American Associations for Dental Research Online Journals
The clinical effects of a mouthrinse containing 0.1% octenidine
B. B. Beiswanger, M. E. Mallatt, M. S. Mau, R. D. Jackson and D. K. Hennon
Oral Health Research Institute, Indiana University School of Dentistry, Indianapolis 16202.
The purpose of this three-month clinical trial was to evaluate the effects
of a 0.1% octenidine mouthrinse on plaque, gingivitis, extrinsic dental
stain, and the oral soft tissues. A total of 451 adult volunteer subjects
was initiated into the study and given baseline dental examinations. The
subjects were stratified into two balanced groups according to gender,
plaque, and gingivitis scores. The subjects then received a dental
prophylaxis and were provided with dentifrice, toothbrushes, and either a
mouthrinse containing 0.1% octenidine dihydrochloride as the active
ingredient or a similar placebo mouthrinse. Subjects were instructed to
rinse with their assigned product for 30 s twice each day. Examinations
were repeated at six weeks (soft-tissue assessment, gingivitis) and three
months (soft tissues, plaque, gingivitis, dental stain). The results showed
that the group rinsing with 0.1% octenidine had significantly less plaque
(39%), gingivitis (50%), and bleeding sites (60%) than the group using the
control product, but had significantly higher stain formation and
experienced longer prophylaxis times to remove the stain. The oral
soft-tissue examinations revealed no differences in the groups in either
the numbers or types of lesions noted.
