Journal of Dental Research, Vol 68, 1519-1524, Copyright © 1989 by International & American Associations for Dental Research Online Journals
Microscopic and crystallographic examinations of the teeth of the X-linked hypophosphatemic mouse
K. Abe, T. Ooshima, Y. Masatomi, S. Sobue and Y. Moriwaki
Department of Pedodontics, Osaka University Faculty of Dentistry, Japan.
Teeth from the C57BL/6J-Hyp mouse (Hyp mouse) were examined histologically,
radiographically, and crystallographically. Microscopic examinations of the
ground sections, the decalcified and H-E-stained sections, and the contact
microradiograms of molars and incisors from the Hyp mouse showed several
abnormalities--such as large pulp chamber, wide predentin, thin dentin at
the pulp floor, and multiple occurrences of interglobular dentin. Powder
and microbeam x-ray diffraction analyses showed that the crystallinity of
hydroxyapatite in incisor globular dentin from the Hyp mouse was higher
than that in incisor dentin from the normal mouse. On the other hand, the
findings of transmission electron microscopy demonstrated that the sizes of
hydroxyapatite crystals of globular dentin in the Hyp incisor were larger
than those in normal incisor dentin. These results demonstrated that the
findings in Hyp mouse teeth were in accord with those of human XLH teeth.
