Journal of Dental Research, Vol 68, 72-77, Copyright © 1989 by International & American Associations for Dental Research Online Journals

ARTICLES

Influence of milk and food on fluoride bioavailability from NaF and Na2FPO3 in man

K. Trautner and J. Einwag
Dental School, University of Wurzburg, Federal Republic of Germany.

Aqueous solutions of NaF and sodium monofluorophosphate (MFP) were given to fasting young adults in an intra-individual cross-over study. Plasma fluoride (F) levels were measured by use of a F-ion-sensitive electrode, and eight-hour profiles of F concentrations in plasma were determined. F availability and pharmacokinetic data were identical for both substances. Furthermore, the same subjects were given tablets containing 2 mg F, either as NaF or as MFP, under different experimental regimens: (a) on a fasting stomach, (b) together with milk, or (c) together with breakfast and milk. Equal F availabilities were observed for both substances. Plasma peak levels were reduced when the tablets were taken together with food. Intake of milk reduced F availability by 30% compared with the fasting stomach experiment; this effect was abolished when milk was taken as part of the breakfast. It is suggested that formation of Ca salts and entrapment of F in coagulation products of milk are important factors causing reduction of F availability, and that prolonged stay of the chyme after concomitant ingestion of food allows F to become liberated from bound forms and coagulation products by digestion processes.

This article has been cited by other articles:

				J.A. Cury, F.S. Del Fiol, L.M.A. Tenuta, and P.L. Rosalen Low-fluoride Dentifrice and Gastrointestinal Fluoride Absorption after Meals J. Dent. Res., December 1, 2005; 84(12): 1133 - 1137. [Abstract] [Full Text] [PDF]