Journal of Dental Research, Vol 67, 959-963, Copyright © 1988 by International & American Associations for Dental Research Online Journals
Effects of rinses with an acidic calcium phosphate solution on fluoride uptake, caries, and in situ plaque pH in rats
C. T. Schreiber, R. J. Shern, L. C. Chow and A. Kingman
American Dental Association Health Foundation, Paffenbarger Research Center, National Bureau of Standards, Gaithersburg, Maryland 20899.
The effects of oral rinses on enamel fluoride uptake, caries, and plaque pH
in rats were investigated by use of (1) an acidic calcium phosphate
solution (CPS) saturated with dicalcium phosphate dihydrate (DCPD) and (2)
a 1% fluoride solution. Osborne-Mendel rats, 19 days of age, were randomly
assigned to one of four mouth-rinse treatment groups, with the two
consecutively administered rinses being: H2O-H2O; H2O-F; CPS-H2O; and
CPS-F. The treatments were administered on days 1 through 4, and the
animals were provided with a cariogenic challenge throughout the study. The
groups treated with F exhibited significantly higher mean levels of
enamel-bound F than did the non-F groups. Furthermore, CPS significantly
increased uptake of F by enamel when used as an adjunct to the F treatment.
The caries scores of the CPS-F and H2O-F groups were not statistically
different; however, a strong negative correlation was observed between
enamel F content and caries scores, indicating that as more F was
incorporated into the teeth, less caries formation occurred. Despite the
significant differences in enamel F and caries scores among some of the
treatment groups, post mortem in situ plaque pH drop in response to a
sucrose rinse showed no differences among these groups.
