Journal of Dental Research, Vol 67, 46-50, Copyright © 1988 by International & American Associations for Dental Research Online Journals

ARTICLES

The effect of long-term use of a dentifrice containing zinc citrate and a non-ionic agent on the oral flora

C. L. Jones, J. A. Ritchie, P. D. Marsh and F. Van der Ouderaa
Unilever Research, Gibbs Dental Division, Port Sunlight Laboratory, Merseyside, United Kingdom.

The effect on the oral ecology of daily use, for seven months, of a dentifrice containing 0.5% (w/w) zinc citrate and a non-ionic agent, i.e., 0.2% (w/w) Triclosan (2,4,4'-trichloro-2'-hydroxydiphenyl ether), has been monitored on 13 adult volunteers. Plaque and saliva were sampled monthly and the bacterial flora analyzed. Twenty-six volunteers used a placebo dentifrice as part of their normal oral hygiene for four months to establish the baseline microbial flora. The volunteers were then split into two equal groups: One group continued to use the placebo dentifrice; the other used the dentifrice containing zinc citrate and Triclosan. There was no evidence that seven months' use of a dentifrice containing 0.5% zinc citrate and 0.2% Triclosan caused shifts in the oral microbial ecology, nor was there any evidence of developing bacterial resistance to Triclosan.

This article has been cited by other articles:

				A. J. McBain, R. G. Ledder, P. Sreenivasan, and P. Gilbert Selection for high-level resistance by chronic triclosan exposure is not universal J. Antimicrob. Chemother., May 1, 2004; 53(5): 772 - 777. [Abstract] [Full Text] [PDF]

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