Journal of Dental Research, Vol 66, 1061-1065, Copyright © 1987 by International & American Associations for Dental Research Online Journals
Pharmacokinetic aspects of topical fluorides
J. Ekstrand
Pharmacokinetic studies have revealed quantitative information about the
bioavailability, rate of absorption, distribution, and clearance of
fluoride following the use of fluoride-containing dentifrices, gels,
varnishes, and solutions. It is concluded that following the use of topical
fluoride products, variable amounts of fluoride are swallowed and absorbed
into the systemic circulation--amounts which may be sufficient to produce
acute or chronic side-effects. Pharmacokinetic data should, therefore, form
part of the basis for the optimal and safe use of fluoride products. In
addition, there is a need for future research to determine the kinetics of
fluoride in the oral fluids after the application of topical fluoride
agents and to determine the associated changes in the composition of the
mineral components of the oral fluids.
