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Journal of Dental Research, Vol 66, 1538-1542, Copyright © 1987 by International & American Associations for Dental Research Online Journals

ARTICLES

Pharmacological evaluation of an intra-oral fluoride-releasing device in adolescents

K. Kula, T. Kula, W. Davidson and E. Parker

The purpose of this study was to quantify fluoride (F) concentrations in body fluids of adolescents wearing two intra-oral fluoride-releasing devices (IFRDs) designed to release 0.10 mg F/day. Fluoride concentrations were determined potentiometrically. No significant increases occurred in urine or serum F concentrations during the 26-week device phase. Elevated salivary F concentrations were maintained throughout the device phase when broken or depleted IFRDs were replaced. However, salivary F concentrations returned to pre-device phase values by 26 weeks when the original IFRDs were maintained. These findings suggest that IFRDs can significantly elevate salivary F concentrations of adolescents without significant elevations in systemic F concentrations.




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