Journal of Dental Research, Vol 65, 695-697, Copyright © 1986 by International & American Associations for Dental Research Online Journals
Effect of antimicrobial agents on root surface caries, alveolar bone loss, and microflora in rice rats
A. Toth, F. M. Beck, E. X. Beck, N. Flaxman and S. Rosen
Two antimicrobial agents, 9-aminoacridine (0.2%) and minocycline (0.2%),
were evaluated for their efficacy in inhibiting root surface caries, bone
loss, and microflora in rice rats. A solution of 5000 ppm fluoride was used
as a positive control for the inhibition of root surface caries, and
double-distilled water was used as a negative control group. Each rat was
treated by having its molar teeth swabbed 2 X per day with the prescribed
agent in its group for nine weeks. Root caries reduction in the minocycline
and fluoride groups was not significantly different, but the reduction was
significantly greater than in the 9-aminoacridine group, with the caries
score in all three groups being significantly less than that in the water
control. Bone loss reduction for the minocycline group was significantly
greater than that for any other group.
