Journal of Dental Research, Vol 64, 1281-1285, Copyright © 1985 by International & American Associations for Dental Research Online Journals
Effects of a single intravenous dose of sodium fluoride on plasma electrolytes and metabolites in rats, rabbits, and cockerels
P. A. Monsour, B. J. Kruger and J. R. Smid
This study assessed the effect of a single intravenous dose of sodium
fluoride (20 mg/kg body wt.) on plasma ionic fluoride and on some other
plasma electrolytes and metabolites in rats, rabbits, and cockerels. At any
given time following sodium fluoride administration, the plasma ionic
fluoride was highest in rabbits and lowest in cockerels. The rate of
removal of fluoride from plasma was slower in rabbits as compared with that
in the other two species. Plasma sodium, chloride, total protein, albumin,
total globulins, and osmolality were not significantly altered by sodium
fluoride in any of these three species. However, plasma phosphate
(inorganic), urea, creatinine, and glucose were elevated, and plasma
calcium was reduced in the rats and the rabbits, but none was significantly
altered in the cockerels. The analyses indicated that species variability
does exist in fluoride toxicity.
