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Journal of Dental Research, Vol 64, 1214-1217, Copyright © 1985 by International & American Associations for Dental Research Online Journals

ARTICLES

Toxicological assessment of lidocaine in the pregnant rat

L. J. Ramazzotto, F. A. Curro, J. A. Paterson, P. Tanner and M. Coleman

Teratogenic and toxicological effects of lidocaine administered during pregnancy were evaluated in the Sprague Dawley rat. High doses of lidocaine administered during specific periods of gestation were shown to produce no apparent adverse toxicological or teratogenic effects. Histological, enzymological, and physical features of the fetuses, utilizing conventional toxicological parameters, were all found to be normal following maternal administration of lidocaine. Analysis of these data suggests that the administration of lidocaine during pregnancy had no detectable adverse effects on the fetus.


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