Journal of Dental Research, Vol 63, 1130-1135, Copyright © 1984 by International & American Associations for Dental Research Online Journals
Acceleration of remineralization in vitro by sodium monofluorophosphate and sodium fluoride
J. R. Mellberg and D. E. Mallon
Sixteen groups of artificial caries lesions were treated with from 75-900
ppm F from MFP, NaF, combinations of the two, or water for five min twice
daily for ten days. Between treatments, the lesions were placed in a
remineralizing solution at 37 degrees C. Quantitative microradiography of
the treated lesions vs. matched untreated lesions showed significant
remineralization of the surface layer and lesion body of all groups,
including the water-treated control group. Fluoride treatments improved
remineralization. Increasing the concentration of NaF had only a small
effect on remineralization, but MFP was more effective at higher
concentrations. Evaluation of MFP/NaF mixtures showed that greatest
remineralization was obtained from a 75/225 ppm F ratio of NaF/MFP. This
combination of F- and PO3F= was more effective than a fluoride
concentration of 300 ppm F from either agent alone.
