Journal of Dental Research, Vol 63, 890-893, Copyright © 1984 by International & American Associations for Dental Research Online Journals
Inhibitory effect of inositol phosphates on parathyroid hormone-induced bone resorption in organ cultures
B. C. Gomes, H. W. Kaufman, J. R. Bloom, J. Navon, T. J. Wilkens and R. A. Rifkin
This study investigates the ability of phytic acid, its inositol phosphate
derivatives (inositol penta-, tetra-, tri-, di-, and monophosphate), and
inorganic phosphate to inhibit parathyroid hormone (PTH)-induced resorption
of fetal rat long bones in organ culture. Pregnant rats injected with 45Ca
on the 18th day of gestation were killed the next day and their fetuses
removed. Half of each pair of dissected long bones was incubated in a
chemically defined control medium, while the contralateral half was
incubated in medium containing PTH or PTH plus the phosphate compound to be
tested. 45Ca released into the medium was indicative of the amount of bone
resorption. All phosphate compounds tested inhibited resorption. The
inositol phosphates should be studied further to assess their suitability
as therapeutic agents for treatment of metabolic bone diseases involving
increased turnover.
