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Journal of Dental Research, Vol 63, 82-86, Copyright © 1984 by International & American Associations for Dental Research Online Journals

ARTICLES

Reserpinization: effects on parotid gland function

E. Watson, F. Dowd, K. Jacobson and H. Horwitz

Chronic reserpinization of mice and rabbits affected parotid gland function; cholinergic and beta-adrenergic-stimulated amylase release were significantly reduced, and cyclic-AMP and cyclic-GMP levels were significantly elevated above control-stimulated levels. Amylase released by dibutyryl-c-AMP was also reduced, suggesting a defect in stimulus-secretion coupling subsequent to c-AMP formation.




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